Ontology highlight
ABSTRACT:
SUBMITTER: Knolle MD
PROVIDER: S-EPMC3679335 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Knolle Martin D MD Nakajima Takahiro T Hergrueter Anja A Gupta Kushagra K Polverino Francesca F Craig Vanessa J VJ Fyfe Susanne E SE Zahid Muhammad M Permaul Perdita P Cernadas Manuela M Montano Gilbert G Tesfaigzi Yohannes Y Sholl Lynette L Kobzik Lester L Israel Elliot E Owen Caroline A CA
Journal of immunology (Baltimore, Md. : 1950) 20130513 12
To determine whether a disintegrin and metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyperresponsiveness (AHR), we compared AAI and AHR in wild-type (WT) versus Adam8(-/-) mice in different genetic backgrounds sensitized and challenged with OVA or house dust mite protein extract. OVA- and house dust mite-treated Adam8(-/-) mice had higher lung leukocyte counts, more airway mucus metaplasia, greater lung levels of some Th2 cytokines, and higher methacholine-i ...[more]