Ontology highlight
ABSTRACT:
SUBMITTER: Brautbar A
PROVIDER: S-EPMC3679399 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Brautbar Ariel A Barbalic Maja M Chen Fengju F Belmont John J Virani Salim S SS Scherer Steve S Hegele Robert A RA Ballantyne Christie M CM
Journal of lipid research 20130430 7
Individuals with mixed dyslipidemia, including high triglycerides (TGs) and low high density lipoprotein cholesterol (HDL-C), have increased risk for coronary events. We examined the effect of rare genetic variants in the APOA5 gene region on plasma HDL-C, apolipoprotein A-I (apoA-I), and TG response to fenofibric acid monotherapy and in combination with statins. The APOA5 gene region was sequenced in 1,612 individuals with mixed dyslipidemia in a randomized trial of fenofibric acid alone and in ...[more]