Ontology highlight
ABSTRACT:
SUBMITTER: Feng Q
PROVIDER: S-EPMC3873874 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Feng Q Q Vickers K C KC Anderson M P MP Levin M G MG Chen W W Harrison D G DG Wilke R A RA
Nature communications 20130101
Type 1 cannabinoid receptor blockers increase high-density lipoprotein cholesterol levels. Although genetic variation in the type 1 cannabinoid receptor--encoded by the CNR1 gene--is known to influence high-density lipoprotein cholesterol level as well, human studies conducted to date have been limited to genetic markers such as haplotype-tagging single nucleotide polymorphisms. Here we identify rs806371 in the CNR1 promoter as the causal variant. We re-sequence the CNR1 gene and genotype all va ...[more]