Ontology highlight
ABSTRACT:
SUBMITTER: Biswas S
PROVIDER: S-EPMC3679453 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Cell death and differentiation 20130308 7
Multicellular organisms maintain genomic integrity and resist tumorigenesis through a tightly regulated DNA damage response (DDR) that prevents propagation of deleterious mutations either through DNA repair or programmed cell death. An impaired DDR leads to tumorigenesis that is accelerated when programmed cell death is prevented. Loss of the ATM (ataxia telangiectasia mutated)-mediated DDR in mice results in T-cell leukemia driven by accumulation of DNA damage accrued during normal T-cell devel ...[more]