Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen PM
PROVIDER: S-EPMC7206067 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell death and differentiation 20190711 2
Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, thereby contributing directly to the regulation of homeostasis. We have shown that from early embryonic development Bcl-G, a Bcl-2 protein family member with unknown function, was highly expressed in gastrointestinal epithelial cells. While Bcl-G was dispensable for normal growth and development in mice, the loss of Bcl-G resulted in accelerated progression of colitis ...[more]