Ontology highlight
ABSTRACT:
SUBMITTER: Conde C
PROVIDER: S-EPMC3680734 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Conde Carlos C Osswald Mariana M Barbosa João J Moutinho-Santos Tatiana T Pinheiro Diana D Guimarães Sofia S Matos Irina I Maiato Helder H Sunkel Claudio E CE
The EMBO journal 20130517 12
Maintenance of genomic stability during eukaryotic cell division relies on the spindle assembly checkpoint (SAC) that prevents mitotic exit until all chromosomes are properly attached to the spindle. Polo is a mitotic kinase proposed to be involved in SAC function, but its role has remained elusive. We demonstrate that Polo and Aurora B functional interdependency comprises a positive feedback loop that promotes Mps1 kinetochore localization and activity. Expression of constitutively active Polo ...[more]