Ontology highlight
ABSTRACT:
SUBMITTER: Isokane M
PROVIDER: S-EPMC4792069 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Isokane Mayumi M Walter Thomas T Mahen Robert R Nijmeijer Bianca B Hériché Jean-Karim JK Miura Kota K Maffini Stefano S Ivanov Miroslav Penchev MP Kitajima Tomoya S TS Peters Jan-Michael JM Ellenberg Jan J
The Journal of cell biology 20160307 6
To prevent genome instability, mitotic exit is delayed until all chromosomes are properly attached to the mitotic spindle by the spindle assembly checkpoint (SAC). In this study, we characterized the function of ARHGEF17, identified in a genome-wide RNA interference screen for human mitosis genes. Through a series of quantitative imaging, biochemical, and biophysical experiments, we showed that ARHGEF17 is essential for SAC activity, because it is the major targeting factor that controls localiz ...[more]