Ontology highlight
ABSTRACT:
SUBMITTER: Hung WL
PROVIDER: S-EPMC3680742 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Hung Wesley L WL Hwang Christine C Gao Shangbang S Liao Edward H EH Chitturi Jyothsna J Wang Ying Y Li Hang H Stigloher Christian C Bessereau Jean-Louis JL Zhen Mei M
The EMBO journal 20130510 12
A neuronal F-box protein FSN-1 regulates Caenorhabditis elegans neuromuscular junction development by negatively regulating DLK-mediated MAPK signalling. In the present study, we show that attenuation of insulin/IGF signalling also contributes to FSN-1-dependent synaptic development and function. The aberrant synapse morphology and synaptic transmission in fsn-1 mutants are partially and specifically rescued by reducing insulin/IGF-signalling activity in postsynaptic muscles, as well as by reduc ...[more]