Ontology highlight
ABSTRACT:
SUBMITTER: Takayama K
PROVIDER: S-EPMC3680743 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Takayama Ken-Ichi K Horie-Inoue Kuniko K Katayama Shintaro S Suzuki Takashi T Tsutsumi Shuichi S Ikeda Kazuhiro K Urano Tomohiko T Fujimura Tetsuya T Takagi Kiyoshi K Takahashi Satoru S Homma Yukio Y Ouchi Yasuyoshi Y Aburatani Hiroyuki H Hayashizaki Yoshihide Y Inoue Satoshi S
The EMBO journal 20130503 12
High-throughput techniques have identified numerous antisense (AS) transcripts and long non-coding RNAs (ncRNAs). However, their significance in cancer biology remains largely unknown. Here, we report an androgen-responsive long ncRNA, CTBP1-AS, located in the AS region of C-terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor. CTBP1-AS is predominantly localized in the nucleus and its expression is generally upregulated in prostate cancer. CTBP1-AS promotes both horm ...[more]