Ontology highlight
ABSTRACT:
SUBMITTER: Rupaimoole R
PROVIDER: S-EPMC4691557 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Rupaimoole Rajesha R Lee Jaehyuk J Haemmerle Monika M Ling Hui H Previs Rebecca A RA Pradeep Sunila S Wu Sherry Y SY Ivan Cristina C Ferracin Manuela M Dennison Jennifer B JB Millward Niki M Zacharias NMZ Nagaraja Archana S AS Gharpure Kshipra M KM McGuire Michael M Sam Nidhin N Armaiz-Pena Guillermo N GN Sadaoui Nouara C NC Rodriguez-Aguayo Cristian C Calin George A GA Calin George A GA Drapkin Ronny I RI Kovacs Jeffery J Mills Gordon B GB Zhang Wei W Lopez-Berestein Gabriel G Bhattacharya Pratip K PK Sood Anil K AK
Cell reports 20151210 11
Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, and knockdown of NRCP resulted in significantly increased apoptosis, decreased cell proliferation, and decreased glycolysis compared with control cancer cells. In an orthotopic mouse ...[more]