Ontology highlight
ABSTRACT:
SUBMITTER: de Graffenried CL
PROVIDER: S-EPMC3681699 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
de Graffenried Christopher L CL Anrather Dorothea D Von Raußendorf Freia F Warren Graham G
Molecular biology of the cell 20130424 12
In the protist parasite Trypanosoma brucei, the single Polo-like kinase (TbPLK) controls the inheritance of a suite of organelles that help position the parasite's single flagellum. These include the basal bodies, the bilobe, and the flagellar attachment zone (FAZ). TbCentrin2 was previously shown to be a target for TbPLK in vitro, and this is extended in this study to in vivo studies, highlighting a crucial role for serine 54 in the N-terminal domain. Duplication of the bilobe correlates with t ...[more]