Ontology highlight
ABSTRACT:
SUBMITTER: Quinlivan EP
PROVIDER: S-EPMC3681792 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Quinlivan Eoin P EP Crider Krista S KS Zhu Jiang-Hui JH Maneval David R DR Hao Ling L Li Zhu Z Rasmussen Sonja A SA Berry R J RJ Bailey Lynn B LB
PloS one 20130613 6
Vitamin B12, a co-factor in methyl-group transfer, is important in maintaining DNA (deoxycytidine) methylation. Using two independent assays we examined the effect of vitamin B12-deficiency (plasma vitamin B12<148 pmol/L) on DNA methylation in women of childbearing age. Coagulated blood clot DNA from vitamin B12-deficient women had significantly (p<0.001) lower percentage deoxycytidine methylation (3.23±0.66%; n = 248) and greater [3 H]methyl-acceptance (42,859±9,699 cpm; n = 17) than DNA from B ...[more]