Conformational switching in the fungal light sensor Vivid.
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ABSTRACT:
SUBMITTER: Zoltowski BD
PROVIDER: S-EPMC3682417 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
Conformational switching in the fungal light sensor Vivid.
Zoltowski Brian D BD Schwerdtfeger Carsten C Widom Joanne J Loros Jennifer J JJ Bilwes Alexandrine M AM Dunlap Jay C JC Crane Brian R BR
Science (New York, N.Y.) 20070501 5827
The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, oxygen, or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates the flavin cofactor. Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change. A cysteine-to-serine substitution remote from the flavi ...[more]
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