Ontology highlight
ABSTRACT:
SUBMITTER: Villacampa P
PROVIDER: S-EPMC3682564 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Villacampa Pilar P Ribera Albert A Motas Sandra S Ramírez Laura L García Miquel M de la Villa Pedro P Haurigot Virginia V Bosch Fatima F
The Journal of biological chemistry 20130425 24
Insulin-like growth factor I (IGF-I) exerts multiple effects on different retinal cell types in both physiological and pathological conditions. Despite the growth factor's extensively described neuroprotective actions, transgenic mice with increased intraocular levels of IGF-I showed progressive impairment of electroretinographic amplitudes up to complete loss of response, with loss of photoreceptors and bipolar, ganglion, and amacrine neurons. Neurodegeneration was preceded by the overexpressio ...[more]