Ontology highlight
ABSTRACT:
SUBMITTER: Ye F
PROVIDER: S-EPMC3682565 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Ye Fei F Zhang Jie J Liu Hongchuan H Hilgenfeld Rolf R Zhang Ruihan R Kong Xiangqian X Li Lianchun L Lu Junyan J Zhang Xinlei X Li Donghai D Jiang Hualiang H Yang Cai-Guang CG Luo Cheng C
The Journal of biological chemistry 20130426 24
The ATP-dependent Clp protease (ClpP) plays an essential role not only in the control of protein quality but also in the regulation of bacterial pathogen virulence, making it an attractive target for antibacterial treatment. We have previously determined the crystal structures of Staphylococcus aureus ClpP (SaClpP) in two different states, extended and compressed. To investigate the dynamic switching of ClpP between these states, we performed a series of molecular dynamics simulations. During th ...[more]