Ontology highlight
ABSTRACT:
SUBMITTER: Cywes-Bentley C
PROVIDER: S-EPMC3683766 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cywes-Bentley Colette C Skurnik David D Zaidi Tanweer T Roux Damien D Deoliveira Rosane B RB Garrett Wendy S WS Lu Xi X O'Malley Jennifer J Kinzel Kathryn K Zaidi Tauqeer T Rey Astrid A Perrin Christophe C Fichorova Raina N RN Kayatani Alexander K K AK Maira-Litràn Tomas T Gening Marina L ML Tsvetkov Yury E YE Nifantiev Nikolay E NE Bakaletz Lauren O LO Pelton Stephen I SI Golenbock Douglas T DT Pier Gerald B GB
Proceedings of the National Academy of Sciences of the United States of America 20130528 24
Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple pathogens. A β-(1→6)-linked poly-N-acetyl-d-glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designated intercellular adhesion in Staphylococcus aureus or polyglucosamine in selected Gram-negative bacterial pathogens. We report that many microbial pathogens lacking an identifiable intercellular adhe ...[more]