Ontology highlight
ABSTRACT:
SUBMITTER: Ito K
PROVIDER: S-EPMC39265 | biostudies-other | 1996 May
REPOSITORIES: biostudies-other
Ito K K Ebihara K K Uno M M Nakamura Y Y
Proceedings of the National Academy of Sciences of the United States of America 19960501 11
Translation termination requires two codon-specific polypeptide release factors in prokaryotes and one omnipotent factor in eukaryotes. Sequences of 17 different polypeptide release factors from prokaryotes and eukaryotes were compared. The prokaryotic release factors share residues split into seven motifs. Conservation of many discrete, perhaps critical, amino acids is observed in eukaryotic release factors, as well as in the C-terminal portion of elongation factor (EF) G. Given that the C-term ...[more]