Ontology highlight
ABSTRACT:
SUBMITTER: Raman K
PROVIDER: S-EPMC3685167 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Raman Karthik K Mencio Caitlin C Desai Umesh R UR Kuberan Balagurunathan B
Molecular pharmaceutics 20130227 4
Heparin is a highly sulfated polysaccharide that serves biologically relevant roles as an anticoagulant and anticancer agent. While it is well-known that modification of heparin's sulfation pattern can drastically influence its ability to bind growth factors and other extracellular molecules, very little is known about the cellular uptake of heparin and the role sulfation patterns serve in affecting its internalization. In this study, we chemically synthesized several fluorescently labeled hepar ...[more]