Ontology highlight
ABSTRACT:
SUBMITTER: Kowalski MP
PROVIDER: S-EPMC3685177 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Kowalski Michael P MP Dubouix-Bourandy Anne A Bajmoczi Milan M Golan David E DE Zaidi Tanweer T Coutinho-Sledge Yamara S YS Gygi Melanie P MP Gygi Steven P SP Wiemer Erik A C EA Pier Gerald B GB
Science (New York, N.Y.) 20070701 5834
The airway epithelium plays an essential role in innate immunity to lung pathogens. Ribonucleoprotein particles primarily composed of major vault protein (MVP) are highly expressed in cells that encounter xenobiotics. However, a clear biologic function for MVP is not established. We report here that MVP is rapidly recruited to lipid rafts when human lung epithelial cells are infected with Pseudomonas aeruginosa, and maximal recruitment is dependent on bacterial binding to the cystic fibrosis tra ...[more]