Ontology highlight
ABSTRACT:
SUBMITTER: Ben J
PROVIDER: S-EPMC6470148 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ben Jingjing J Jiang Bin B Wang Dongdong D Liu Qingling Q Zhang Yongjing Y Qi Yu Y Tong Xing X Chen Lili L Liu Xianzhong X Zhang Yan Y Zhu Xudong X Li Xiaoyu X Zhang Hanwen H Bai Hui H Yang Qing Q Ma Junqing J Wiemer Erik A C EAC Xu Yong Y Chen Qi Q
Nature communications 20190417 1
Macrophage-orchestrated, low-grade chronic inflammation plays a pivotal role in obesity and atherogenesis. However, the underlying regulatory mechanisms remain incompletely understood. Here, we identify major vault protein (MVP), the main component of unique cellular ribonucleoprotein particles, as a suppressor for NF-κB signaling in macrophages. Both global and myeloid-specific MVP gene knockout aggravates high-fat diet induced obesity, insulin resistance, hepatic steatosis and atherosclerosis ...[more]