Interferon-? therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever.
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ABSTRACT:
SUBMITTER: Smith LM
PROVIDER: S-EPMC3685222 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever.
Smith Lauren M LM Hensley Lisa E LE Geisbert Thomas W TW Johnson Joshua J Stossel Andrea A Honko Anna A Yen Judy Y JY Geisbert Joan J Paragas Jason J Fritz Elizabeth E Olinger Gene G Young Howard A HA Rubins Kathleen H KH Karp Christopher L CL
The Journal of infectious diseases 20121218 2
There is a clear need for novel, effective therapeutic approaches to hemorrhagic fever due to filoviruses. Ebola virus hemorrhagic fever is associated with robust interferon (IFN)-α production, with plasma concentrations of IFN-α that greatly (60- to 100-fold) exceed those seen in other viral infections, but little IFN-β production. While all of the type I IFNs signal through the same receptor complex, both quantitative and qualitative differences in biological activity are observed after stimul ...[more]
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