Ontology highlight
ABSTRACT:
SUBMITTER: Douglas AD
PROVIDER: S-EPMC3685228 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20130409 2
Controlled human malaria infection is used to measure efficacy of candidate malaria vaccines before field studies are undertaken. Mathematical modeling using data from quantitative polymerase chain reaction (qPCR) parasitemia monitoring can discriminate between vaccine effects on the parasite's liver and blood stages. Uncertainty regarding the most appropriate modeling method hinders interpretation of such trials. We used qPCR data from 267 Plasmodium falciparum infections to compare linear, sin ...[more]