Ontology highlight
ABSTRACT:
SUBMITTER: He B
PROVIDER: S-EPMC3686076 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
He Bifang B Mao Canquan C Ru Beibei B Han Hesong H Zhou Peng P Huang Jian J
Computational and mathematical methods in medicine 20130603
Metuximab is the generic name of Licartin, a new drug for radioimmunotherapy of hepatocellular carcinoma. Although it is known to be a mouse monoclonal antibody against CD147, the complete epitope mediating the binding of metuximab to CD147 remains unknown. We panned the Ph.D.-12 phage display peptide library against metuximab and got six mimotopes. The following bioinformatics analysis based on mimotopes suggested that metuximab recognizes a conformational epitope composed of more than 20 resid ...[more]