Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhri VK
PROVIDER: S-EPMC3686965 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Chaudhri Virendra K VK Salzler Gregory G GG Dick Salihah A SA Buckman Melanie S MS Sordella Raffaella R Karoly Edward D ED Mohney Robert R Stiles Brendon M BM Elemento Olivier O Altorki Nasser K NK McGraw Timothy E TE
Molecular cancer research : MCR 20130308 6
Cancer cells undergo a metabolic reprogramming but little is known about metabolic alterations of other cells within tumors. We use mass spectrometry-based profiling and a metabolic pathway-based systems analysis to compare 21 primary human lung cancer-associated fibroblast lines (CAF) to "normal" fibroblast lines (NF) generated from adjacent nonneoplastic lung tissue. CAFs are protumorigenic, although the mechanisms by which CAFs support tumors have not been elucidated. We have identified sever ...[more]