Ontology highlight
ABSTRACT:
SUBMITTER: Kerr BA
PROVIDER: S-EPMC3687027 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Kerr B A BA McCabe N P NP Feng W W Byzova T V TV
Oncogene 20130915 36
Although the survival rate for early detected cancers is high, once a cancer metastasizes to bone, it is incurable. Interestingly, patients without visible metastases display abnormal bone formation and resorption, suggesting a link between primary cancers and the bone microenvironment prior to metastasis, and this link likely facilitates preparation of the pre-metastatic niche. We hypothesized that communication with the primary tumor would result in bone remodeling alterations, and that platel ...[more]