Ontology highlight
ABSTRACT:
SUBMITTER: Venkova-Canova T
PROVIDER: S-EPMC3688505 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Venkova-Canova Tatiana T Baek Jong Hwan JH Fitzgerald Peter C PC Blokesch Melanie M Chattoraj Dhruba K DK
PLoS genetics 20130620 6
Understanding the mechanisms that coordinate replication initiation with subsequent segregation of chromosomes is an important biological problem. Here we report two replication-control mechanisms mediated by a chromosome segregation protein, ParB2, encoded by chromosome II of the model multichromosome bacterium, Vibrio cholerae. We find by the ChIP-chip assay that ParB2, a centromere binding protein, spreads beyond the centromere and covers a replication inhibitory site (a 39-mer). Unexpectedly ...[more]