Dataset Information

Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.

ABSTRACT:

Background

Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association.

Methodology and principal findings

We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; 1.04-1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03-1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain.

Conclusions

In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.

SUBMITTER: Nyberg ST

PROVIDER: S-EPMC3688665 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.

Nyberg Solja T ST Fransson Eleonor I EI Heikkilä Katriina K Alfredsson Lars L Casini Annalisa A Clays Els E De Bacquer Dirk D Dragano Nico N Erbel Raimund R Ferrie Jane E JE Hamer Mark M Jöckel Karl-Heinz KH Kittel France F Knutsson Anders A Ladwig Karl-Heinz KH Lunau Thorsten T Marmot Michael G MG Nordin Maria M Rugulies Reiner R Siegrist Johannes J Steptoe Andrew A Westerholm Peter J M PJ Westerlund Hugo H Theorell Töres T Brunner Eric J EJ Singh-Manoux Archana A Batty G David GD Kivimäki Mika M

PloS one 20130620 6

<h4>Background</h4>Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association.<h4>Methodology and principal findings</h4>We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following car ...[more]

PMID: 23840664

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Dataset Information

Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.

Background

Methodology and principal findings

Conclusions

Publications

Job strain and cardiovascular disease risk factors: meta-analysis of individual-participant data from 47,000 men and women.

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