Ontology highlight
ABSTRACT:
SUBMITTER: Barsoum IB
PROVIDER: S-EPMC3688755 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Barsoum Ivraym B IB Kaur Jaspreet J Ge Renshan S RS Cooke Paul S PS Yao Humphrey Hung-Chang HH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130408 7
Testes contain two distinct Leydig cell populations during development: fetal and adult Leydig cells (FLCs and ALCs, respectively). ALCs are not derived from FLCs, and it is unknown whether these two populations share common progenitors. We discovered that hedgehog (Hh) signaling is responsible for transforming steroidogenic factor 1-positive (SF1(+)) progenitors into FLCs. However, not all SF1(+) progenitors become FLCs, and some remain undifferentiated through fetal development. We therefore h ...[more]