Ontology highlight
ABSTRACT: Objectives
Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA.Methods
A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data.Results
Significant evidence of association was detected for nine SNPs within the European samples. When meta-analysed with previously published data, 21 SNPs were associated with RA susceptibility. Although SNPs in the PTPN2 gene were previously reported to be associated with RA in both Japanese and European populations, we show genome-wide evidence for a different SNP within this gene associated with RA susceptibility in an independent European population (rs7234029, P?=?4.4×10(-9)).Conclusions
This study provides further genome-wide evidence for the association of the PTPN2 locus (encoding the T cell protein tyrosine phosphastase) with Caucasian RA susceptibility. This finding adds to the growing evidence for PTPN2 being a pan-autoimmune susceptibility gene.
SUBMITTER: Cobb JE
PROVIDER: S-EPMC3688762 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cobb Joanna E JE Plant Darren D Flynn Edward E Tadjeddine Meriem M Dieudé Philippe P Cornélis François F Ärlestig Lisbeth L Dahlqvist Solbritt Rantapää SR Goulielmos George G Boumpas Dimitrios T DT Sidiropoulos Prodromos P Krintel Sophine B SB Ørnbjerg Lykke M LM Hetland Merete L ML Klareskog Lars L Haeupl Thomas T Filer Andrew A Buckley Christopher D CD Raza Karim K Witte Torsten T Schmidt Reinhold E RE FitzGerald Oliver O Veale Douglas D Eyre Stephen S Worthington Jane J
PloS one 20130620 6
<h4>Objectives</h4>Genome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance in studies of Caucasian RA.<h4>Methods</h4>A cohort of 4286 RA patients from across Europe and 5642 population matched controls were genotyped for 25 SNPs, then combined in a meta-analysis with previously published data.<h4>Results</h4>S ...[more]