Ontology highlight
ABSTRACT:
SUBMITTER: Rubio D
PROVIDER: S-EPMC3688842 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cell host & microbe 20130601 6
Nuclear factor kappa B (NF-κB) and type 1 interferon (T1-IFN) signaling are innate immune mechanisms activated upon viral infection. However, the role of NF-κB and its interplay with T1-IFN in antiviral immunity is poorly understood. We show that NF-κB is essential for resistance to ectromelia virus (ECTV), a mouse orthopoxvirus related to the virus causing human smallpox. Additionally, an ECTV mutant lacking an NF-κB inhibitor activates NF-κB more effectively in vivo, resulting in increased pro ...[more]