Ontology highlight
ABSTRACT:
SUBMITTER: Jeoung M
PROVIDER: S-EPMC3689688 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Jeoung Myoungkun M Abdelmoti Lina L Jang Eun Ryoung ER Vander Kooi Craig W CW Galperin Emilia E
PloS one 20130621 6
Shoc2 is a positive regulator of signaling to extracellular signal-regulated protein kinases 1 and 2 (ERK1/2). Shoc2 is also proposed to interact with RAS and Raf-1 in order to accelerate ERK1/2 activity. To understand the mechanisms by which Shoc2 regulates ERK1/2 activation by the epidermal growth factor receptor (EGFR), we dissected the role of Shoc2 structural domains in binding to its signaling partners and its role in regulating ERK1/2 activity. Shoc2 is comprised of two main domains: the ...[more]