Ontology highlight
ABSTRACT:
SUBMITTER: Silveira VS
PROVIDER: S-EPMC7495473 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Silveira Vanessa Silva VS Borges Kleiton Silva KS Santos Verena Silva VS Ruckert Mariana Tannús MT Vieira Gabriela Maciel GM Vasconcelos Elton José Rosas EJR Nagano Luis Fernando Peinado LFP Tone Luiz Gonzaga LG Scrideli Carlos Alberto CA
Scientific reports 20200916 1
SHOC2 scaffold protein has been mainly related to oncogenic ERK signaling through the RAS-SHOC2-PP1 phosphatase complex. In leukemic cells however, SHOC2 upregulation has been previously related to an increased 5-year event-free survival of pediatric pre-B acute lymphoid leukemia, suggesting that SHOC2 could be a potential prognostic marker. To address such paradoxical function, our study investigated how SHOC2 impact leukemic cells drug response. Our transcriptome analysis has shown that SHOC2 ...[more]