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A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle.

ABSTRACT: Polledness is a high impact trait in modern milk and beef production to meet the demands of animal welfare and work safety. Previous studies have mapped the polled-locus to the proximal region of the bovine chromosome 1 (BTA1) and narrowed it down to approximately 1 Mb. Sequencing of the positional candidate genes within the 1 Mb polled region and whole genome sequencing of Holsteins revealed a single nucleotide polymorphism (SNP) AC000158: g.1390292G>A within intron 3 of the interferon gamma receptor 2 gene (IFNGR2) in perfect co-segregation with polledness in Holsteins. This complete association was validated in 443 animals of the same breed. This SNP allows reliable genotyping of horned, heterozygous and homozygous polled Holsteins, even in animals that could not be resolved using the previously published haplotype for Holstein.

SUBMITTER: Glatzer S

PROVIDER: S-EPMC3689702 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle.

Glatzer Sabrina S Merten Nina Johanna NJ Dierks Claudia C Wöhlke Anne A Philipp Ute U Distl Ottmar O

PloS one 20130621 6

Polledness is a high impact trait in modern milk and beef production to meet the demands of animal welfare and work safety. Previous studies have mapped the polled-locus to the proximal region of the bovine chromosome 1 (BTA1) and narrowed it down to approximately 1 Mb. Sequencing of the positional candidate genes within the 1 Mb polled region and whole genome sequencing of Holsteins revealed a single nucleotide polymorphism (SNP) AC000158: g.1390292G>A within intron 3 of the interferon gamma re ...[more]

PMID: 23805331

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Single nucleotide polymorphism and haplotype effects associated with somatic cell score in German Holstein cattle.

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Regulatory Single Nucleotide Polymorphism of the Bovine IFITM3 Gene Induces Differential Transcriptional Capacities of Hanwoo and Holstein Cattle.

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| S-EPMC6962819 | biostudies-literature

A single nucleotide polymorphism in the interferon-γ gene (<i>IFNG</i> +874 T/A) is associated with susceptibility to tuberculosis.

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| S-EPMC5584145 | biostudies-literature

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| S-EPMC1064910 | biostudies-literature

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