Ontology highlight
ABSTRACT:
SUBMITTER: Rychkova A
PROVIDER: S-EPMC3690858 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Rychkova Anna A Mukherjee Shayantani S Bora Ram Prasad RP Warshel Arieh A
Proceedings of the National Academy of Sciences of the United States of America 20130531 25
The nature of the coupling between the stalling of the elongated nascent peptide chain in the ribosome and its insertion through the translocon is analyzed, focusing on the recently discovered biphasic force that overcomes the stalling barrier. The origin of this long-range coupling is explored by coarse-grained simulations that combine the translocon (TR) insertion profile and the effective chemical barrier for the extension of the nascent chain in the ribosome. Our simulation determined that t ...[more]