The hematopoietic stem cell niche--home for friend and foe?
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ABSTRACT:
SUBMITTER: Krause DS
PROVIDER: S-EPMC3691061 | biostudies-literature | 2013 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
The hematopoietic stem cell niche--home for friend and foe?
Krause Daniela S DS Scadden David T DT Preffer Frederic I FI
Cytometry. Part B, Clinical cytometry 20121226 1
The hematopoietic stem cell (HSC) niche is involved in the maintainance and regulation of quiescence, self-renewal and differentiation of hematopoietic stem cells and the fate of their progeny in mammals dealing with the daily stresses to the hematopoietic system. From the discovery that perturbations of the HSC niche can lead to hematopoietic disorders, we have now arrived at the prospect that the HSC niche may play a role in hematological malignancies and that this HSC niche may be a target fo ...[more]
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