Ontology highlight
ABSTRACT:
SUBMITTER: Figueroa CM
PROVIDER: S-EPMC3691274 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Figueroa Carlos M CM Kuhn Misty L ML Falaschetti Christine A CA Solamen Ligin L Olsen Kenneth W KW Ballicora Miguel A MA Iglesias Alberto A AA
PloS one 20130624 6
ADP-glucose pyrophosphorylase regulates the synthesis of glycogen in bacteria and of starch in plants. The enzyme from plants is mainly activated by 3-phosphoglycerate and is a heterotetramer comprising two small and two large subunits. Here, we found that two highly conserved residues are critical for triggering the activation of the potato tuber ADP-glucose pyrophosphorylase, as shown by site-directed mutagenesis. Mutations in the small subunit, which bears the catalytic function in this potat ...[more]