Ontology highlight
ABSTRACT:
SUBMITTER: Bryan C
PROVIDER: S-EPMC3691326 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bryan Christopher C Rice Cory C Harkisheimer Michael M Schultz David C DC Skordalakes Emmanuel E
PloS one 20130624 6
The identification of the human homologue of the yeast CST in 2009 posed a new challenge in our understanding of the mechanism of telomere capping in higher eukaryotes. The high-resolution structure of the human Stn1-Ten1 (hStn1-Ten1) complex presented here reveals that hStn1 consists of an OB domain and tandem C-terminal wHTH motifs, while hTen1 consists of a single OB fold. Contacts between the OB domains facilitate formation of a complex that is strikingly similar to the replication protein A ...[more]