Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC5551977 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Huang Chenhui C Jia Pingping P Chastain Megan M Shiva Olga O Chai Weihang W
Experimental cell research 20170331 2
Maintaining functional telomeres is important for long-term proliferation of cells. About 15% of cancer cells are telomerase-negative and activate the alternative-lengthening of telomeres (ALT) pathway to maintain their telomeres. Recent studies have shown that the human CTC1/STN1/TEN1 complex (CST) plays a multi-faceted role in telomere maintenance in telomerase-expressing cancer cells. However, the role of CST in telomere maintenance in ALT cells is unclear. Here, we report that human CST form ...[more]