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Imaging cell biology in live animals: ready for prime time.

ABSTRACT: Time-lapse fluorescence microscopy is one of the main tools used to image subcellular structures in living cells. Yet for decades it has been applied primarily to in vitro model systems. Thanks to the most recent advancements in intravital microscopy, this approach has finally been extended to live rodents. This represents a major breakthrough that will provide unprecedented new opportunities to study mammalian cell biology in vivo and has already provided new insight in the fields of neurobiology, immunology, and cancer biology.

SUBMITTER: Weigert R

PROVIDER: S-EPMC3691462 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Imaging cell biology in live animals: ready for prime time.

Weigert Roberto R Porat-Shliom Natalie N Amornphimoltham Panomwat P

The Journal of cell biology 20130601 7

Time-lapse fluorescence microscopy is one of the main tools used to image subcellular structures in living cells. Yet for decades it has been applied primarily to in vitro model systems. Thanks to the most recent advancements in intravital microscopy, this approach has finally been extended to live rodents. This represents a major breakthrough that will provide unprecedented new opportunities to study mammalian cell biology in vivo and has already provided new insight in the fields of neurobiolo ...[more]

PMID: 23798727

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