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A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation.
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ABSTRACT:
SUBMITTER: Jiang B
PROVIDER: S-EPMC3691686 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation.
Chemical communications (Cambridge, England) 20111031 6
A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15-30 min with water as the major byproduct, which makes work-up convenient. ...[more]