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A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation.

ABSTRACT: A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15-30 min with water as the major byproduct, which makes work-up convenient.

SUBMITTER: Jiang B

PROVIDER: S-EPMC3691686 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation.

Jiang Bo B Yi Mian-Shuai MS Shi Feng F Tu Shu-Jiang SJ Pindi Suresh S McDowell Patrick P Li Guigen G

Chemical communications (Cambridge, England) 20111031 6

A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15-30 min with water as the major byproduct, which makes work-up convenient. ...[more]

PMID: 22038299

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