Dataset Information
Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5666512 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Ligand-enabled Ir-catalyzed intermolecular diastereoselective and enantioselective allylic alkylation of 3-substituted indoles.
Chemical science 20150608 8
An Ir-catalyzed asymmetric allylic alkylation of 3-substituted indoles is reported. The reaction provides indoline products containing multiple contiguous stereocenters with high site-, regio-, diastereo- and enantioselectivities in one step from a wide range of readily available starting materials. The key to this method is the high level of diastereocontrol enabled by an iridium catalyst derived from a <i>N</i>-aryl phosphoramidite ligand (Me-THQphos, <b>1c</b>). ...[more]