Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection.
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ABSTRACT:
SUBMITTER: Leigh Brown AJ
PROVIDER: S-EPMC369210 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Publications
Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection.
Leigh Brown Andrew J AJ Frost Simon D W SD Good Benjamin B Daar Eric S ES Simon Viviana V Markowitz Martin M Collier Ann C AC Connick Elizabeth E Conway Brian B Margolick Joseph B JB Routy Jean-Pierre JP Corbeil Jacques J Hellmann Nicholas S NS Richman Douglas D DD Little Susan J SJ
Journal of virology 20040301 5
The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration </=0.4-fold that of HIV type 1(NL4-3) (HIV-1(NL4-3)) to ritonavir (hypersusceptibility [HS]). There is also substantial variation in replicative capacity (RC) or an in vitro assay of the contributions of protease (PR) and reverse transcriptase to viral fitness. In chronically infected antiretrovirally treated patients, amprenavir HS has been a ...[more]
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