Ontology highlight
ABSTRACT:
SUBMITTER: Weber J
PROVIDER: S-EPMC1081293 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Weber Jan J Chakraborty Bikram B Weberova Jitka J Miller Michael D MD Quiñones-Mateu Miguel E ME
Journal of clinical microbiology 20050301 3
The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutation K65R confers intermediate levels of resistance to several RT inhibitors, including a three- to fourfold reduction of tenofovir susceptibility. Here, we have used for the first time primary HIV-1 isolates from individuals who developed the K65R mutation while enrolled in a clinical trial of tenofovir to analyze the impact of this mutation on HIV-1 replicative fitness. A marked impairment in replicative ...[more]