Ontology highlight
ABSTRACT:
SUBMITTER: Mullins CD
PROVIDER: S-EPMC3692489 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Mullins Chelsea D CD Su Mack Y MY Hucthagowder Vishwanathan V Chu Liang L Lu Lan L Kulkarni Shashikant S Novack Deborah D Vij Ravi R Tomasson Michael H MH
PloS one 20130625 6
Activating mutations in Ras (N- and K-) are the most common point mutations found in patients with multiple myeloma (MM) and are associated with poor clinical outcome. We sought to directly examine the role of Ras activation in MM pathogenesis and used two different tissue-specific Cre recombinase mouse lines (Cγ1-Cre and AID-Cre), to generate mice with mutant Kras (Kras(G12D) ) activated specifically in germinal center B-cells. We also generated mice with activation of the Kras(G12D) allele in ...[more]