MiRNA expression in pediatric failing human heart.
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ABSTRACT:
SUBMITTER: Stauffer BL
PROVIDER: S-EPMC3694420 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
miRNA expression in pediatric failing human heart.
Stauffer Brian L BL Russell Gloria G Nunley Karin K Miyamoto Shelley D SD Sucharov Carmen C CC
Journal of molecular and cellular cardiology 20130117
miRNAs are short regulatory RNAs that can regulate gene expression through interacting with the 3'UTR of target mRNAs. Although the role of miRNAs has been extensively studied in adult human and animal models of heart disease, nothing is known about their expression in pediatric heart failure patients. Different than adults with heart failure, pediatric patients respond well to phosphodiesterase inhibitor (PDEi) treatment, which is safe in the outpatient setting, results in fewer heart failure e ...[more]
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