Elamipretide Improves Mitochondrial Function in the Failing Human Heart.
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ABSTRACT:
SUBMITTER: Chatfield KC
PROVIDER: S-EPMC6488757 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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Elamipretide Improves Mitochondrial Function in the Failing Human Heart.
Chatfield Kathryn C KC Sparagna Genevieve C GC Chau Sarah S Phillips Elisabeth K EK Ambardekar Amrut V AV Aftab Muhammad M Mitchell Max B MB Sucharov Carmen C CC Miyamoto Shelley D SD Stauffer Brian L BL
JACC. Basic to translational science 20190429 2
Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ex vivo. Freshly explanted failing and nonfailing ventricular tissue from children and adults was treated with elamipretide. Mitochondrial oxygen flux, complex (C) I and CIV activities, and in-gel activity of supercomplex assembly were measured. Mitochondrial functi ...[more]
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