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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

ABSTRACT: Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

SUBMITTER: Monda KL

PROVIDER: S-EPMC3694490 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Monda Keri L KL Chen Gary K GK Taylor Kira C KC Palmer Cameron C Edwards Todd L TL Lange Leslie A LA Ng Maggie C Y MC Adeyemo Adebowale A AA Allison Matthew A MA Bielak Lawrence F LF Chen Guanjie G Graff Mariaelisa M Irvin Marguerite R MR Rhie Suhn K SK Li Guo G Liu Yongmei Y Liu Youfang Y Lu Yingchang Y Nalls Michael A MA Sun Yan V YV Wojczynski Mary K MK Yanek Lisa R LR Aldrich Melinda C MC Ademola Adeyinka A Amos Christopher I CI Bandera Elisa V EV Bock Cathryn H CH Britton Angela A Broeckel Ulrich U Cai Quiyin Q Caporaso Neil E NE Carlson Chris S CS Carpten John J Casey Graham G Chen Wei-Min WM Chen Fang F Chen Yii-Der I YD Chiang Charleston W K CW Coetzee Gerhard A GA Demerath Ellen E Deming-Halverson Sandra L SL Driver Ryan W RW Dubbert Patricia P Feitosa Mary F MF Feng Ye Y Freedman Barry I BI Gillanders Elizabeth M EM Gottesman Omri O Guo Xiuqing X Haritunians Talin T Harris Tamara T Harris Curtis C CC Hennis Anselm J M AJ Hernandez Dena G DG McNeill Lorna H LH Howard Timothy D TD Howard Barbara V BV Howard Virginia J VJ Johnson Karen C KC Kang Sun J SJ Keating Brendan J BJ Kolb Suzanne S Kuller Lewis H LH Kutlar Abdullah A Langefeld Carl D CD Lettre Guillaume G Lohman Kurt K Lotay Vaneet V Lyon Helen H Manson Joann E JE Maixner William W Meng Yan A YA Monroe Kristine R KR Morhason-Bello Imran I Murphy Adam B AB Mychaleckyj Josyf C JC Nadukuru Rajiv R Nathanson Katherine L KL Nayak Uma U N'diaye Amidou A Nemesure Barbara B Wu Suh-Yuh SY Leske M Cristina MC Neslund-Dudas Christine C Neuhouser Marian M Nyante Sarah S Ochs-Balcom Heather H Ogunniyi Adesola A Ogundiran Temidayo O TO Ojengbede Oladosu O Olopade Olufunmilayo I OI Palmer Julie R JR Ruiz-Narvaez Edward A EA Palmer Nicholette D ND Press Michael F MF Rampersaud Evandine E Rasmussen-Torvik Laura J LJ Rodriguez-Gil Jorge L JL Salako Babatunde B Schadt Eric E EE Schwartz Ann G AG Shriner Daniel A DA Siscovick David D Smith Shad B SB Wassertheil-Smoller Sylvia S Speliotes Elizabeth K EK Spitz Margaret R MR Sucheston Lara L Taylor Herman H Tayo Bamidele O BO Tucker Margaret A MA Van Den Berg David J DJ Edwards Digna R Velez DR Wang Zhaoming Z Wiencke John K JK Winkler Thomas W TW Witte John S JS Wrensch Margaret M Wu Xifeng X Yang James J JJ Levin Albert M AM Young Taylor R TR Zakai Neil A NA Cushman Mary M Zanetti Krista A KA Zhao Jing Hua JH Zhao Wei W Zheng Yonglan Y Zhou Jie J Ziegler Regina G RG Zmuda Joseph M JM Fernandes Jyotika K JK Gilkeson Gary S GS Kamen Diane L DL Hunt Kelly J KJ Spruill Ida J IJ Ambrosone Christine B CB Ambs Stefan S Arnett Donna K DK Atwood Larry L Becker Diane M DM Berndt Sonja I SI Bernstein Leslie L Blot William J WJ Borecki Ingrid B IB Bottinger Erwin P EP Bowden Donald W DW Burke Gregory G Chanock Stephen J SJ Cooper Richard S RS Ding Jingzhong J Duggan David D Evans Michele K MK Fox Caroline C Garvey W Timothy WT Bradfield Jonathan P JP Hakonarson Hakon H Grant Struan F A SF Hsing Ann A Chu Lisa L Hu Jennifer J JJ Huo Dezheng D Ingles Sue A SA John Esther M EM Jordan Joanne M JM Kabagambe Edmond K EK Kardia Sharon L R SL Kittles Rick A RA Goodman Phyllis J PJ Klein Eric A EA Kolonel Laurence N LN Le Marchand Loic L Liu Simin S McKnight Barbara B Millikan Robert C RC Mosley Thomas H TH Padhukasahasram Badri B Williams L Keoki LK Patel Sanjay R SR Peters Ulrike U Pettaway Curtis A CA Peyser Patricia A PA Psaty Bruce M BM Redline Susan S Rotimi Charles N CN Rybicki Benjamin A BA Sale Michèle M MM Schreiner Pamela J PJ Signorello Lisa B LB Singleton Andrew B AB Stanford Janet L JL Strom Sara S SS Thun Michael J MJ Vitolins Mara M Zheng Wei W Moore Jason H JH Williams Scott M SM Ketkar Shamika S Zhu Xiaofeng X Zonderman Alan B AB Kooperberg Charles C Papanicolaou George J GJ Henderson Brian E BE Reiner Alex P AP Hirschhorn Joel N JN Loos Ruth J F RJ North Kari E KE Haiman Christopher A CA

Nature genetics 20130414 6

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we includ ...[more]

PMID: 23583978

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Dataset Information

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

Publications

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

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