Ontology highlight
ABSTRACT:
SUBMITTER: Lannutti BJ
PROVIDER: S-EPMC3694505 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Lannutti Brian J BJ Meadows Sarah A SA Herman Sarah E M SE Kashishian Adam A Steiner Bart B Johnson Amy J AJ Byrd John C JC Tyner Jeffrey W JW Loriaux Marc M MM Deininger Mike M Druker Brian J BJ Puri Kamal D KD Ulrich Roger G RG Giese Neill A NA
Blood 20101019 2
Phosphatidylinositol-3-kinase p110δ serves as a central integration point for signaling from cell surface receptors known to promote malignant B-cell proliferation and survival. This provides a rationale for the development of small molecule inhibitors that selectively target p110δ as a treatment approach for patients with B-cell malignancies. We thus identified 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-one (CAL-101), a highly selective and potent p110δ small molecu ...[more]