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Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation.

ABSTRACT: In real time: thrombin activation in vivo can be imaged in real time with ratiometric activatable cell penetrating peptides (RACPPs). RACPPs are designed to combine 1) dual-emission ratioing, 2) far red to infrared wavelengths for in vivo mammalian imaging, and 3) cleavage-dependent spatial localization. The most advanced RACPP uses norleucine (Nle)-TPRSFL as a linker that increases sensitivity to thrombin by about 90-fold.

SUBMITTER: Whitney M 

PROVIDER: S-EPMC3694763 | biostudies-literature |

REPOSITORIES: biostudies-literature

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