Ontology highlight
ABSTRACT:
SUBMITTER: Savariar EN
PROVIDER: S-EPMC3799878 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Cancer research 20121127 2
Management of metastatic disease is integral to cancer treatment. Evaluation of metastases often requires surgical removal of all anatomically susceptible lymph nodes for ex vivo pathologic examination. We report a family of novel ratiometric activatable cell-penetrating peptides, which contain Cy5 as far red fluorescent donor and Cy7 as near-infrared fluorescent acceptor. Cy5 is quenched in favor of Cy7 re-emission until the intervening linker is cut by tumor-associated matrix metalloproteinase ...[more]